Livarise Injection is a 15mg/3mL (5mg/mL) solution containing semaglutide, available as a reusable pen-shaped self-injection device. Lupin launched the product in India under a licensing and supply arrangement with Zydus Lifesciences in March 2026.
Lipid-lowering drug, or so they call it, but semaglutide, if paired with a low-calorie diet and exercise, helps you lose weight. According to the information provided by AusTGA for Wegovy drug, semaglutide is effective for chronic weight management and has a recommended weekly dose escalation schedule.
What Is Livarise Injection Used For?
Livarise contains semaglutide, a GLP-1 receptor agonist that can be prescribed as part of a weight-management programme.
Semaglutide for chronic weight management may be considered for adults with:
- BMI of 30 kg/m² or higher, or
- BMI of 27 kg/m² or higher with at least one weight-related health condition.
Treatment is intended to be combined with a reduced-calorie diet and increased physical activity.
The semaglutide 15mg/3mL formulation from Zydus has also been evaluated in a phase III weight-management study. The study compared the 15mg/3mL formulation with reference semaglutide using the same dose-escalation schedule from 0.25mg to 2.4mg once weekly.
How Does Livarise Work?
Semaglutide works by activating GLP-1 receptors, which are involved in appetite regulation and blood glucose control.
For weight management, its effects include:
- Increasing feelings of fullness
- Reducing hunger and food intake
- Slowing gastric emptying
- Supporting lower calorie intake
- Helping with long-term weight management when combined with lifestyle changes
Because semaglutide affects the digestive system, nausea, vomiting, diarrhoea and constipation are particularly common while the dose is being increased.
How To Use Livarise Injection
Livarise is administered as a once-weekly subcutaneous injection.
The injection is given under the skin, generally in the:
- Abdomen
- Thigh
- Upper arm
It does not matter when during the day you are going to receive an injection. The only thing you have to take care of is that it is not being injected into the vein or muscle!
Sometimes you might see the drug administered from the vials, and other times you might see the cartridge being used along with the injection pen. Regardless, make sure you comprehend the proper way to use the pen and how to load it. Ideally, these things should be shown to you by the physician, nurse or pharmacist.
Do not allow your injection pen or needles to pass between different people.
Livarise Dosage for Weight Loss
The semaglutide weight-management dose is increased gradually to help reduce gastrointestinal side effects.
The Australian TGA dosing schedule for Wegovy is:
| Treatment period | Weekly dose |
| Weeks 1–4 | 0.25mg |
| Weeks 5–8 | 0.5mg |
| Weeks 9–12 | 1mg |
| Weeks 13–16 | 1.7mg |
| Maintenance | 2.4mg |
The usual maintenance dose is 2.4mg given once a week.
Delaying the dose escalation might be necessary in case you have considerable gastrointestinal symptoms until your gastrointestinal state improves.
The clinical trial of semaglutide 15mg/3mL utilized the same stepwise dose increase from 0.25mg to 2.4mg once a week.
Closing remark.
Never change Livarise doses independently. Dosing increment of the medication has to happen as instructed by the physician.
What Happens If You Miss a Livarise Dose?
If a weekly dose is missed, the appropriate action depends on how much time has passed since the scheduled dose.
Australian semaglutide product information contains clear instructions for what to do if a dose is missed. Therefore, you should go by the instructions of a prescribed product you were issued rather than taking an extra dose to cover the missed one.
There should be an interval of time of at least two doses apart before taking the second if the first is not taken. Only your healthcare professional is in position legally to give guidance on such cases.
Possible Side Effects
Common side effects of semaglutide include:
- Nausea
- Vomiting
- Diarrhoea
- Constipation
- Abdominal pain or discomfort
- Headache
- Dizziness
- Fatigue
- Injection-site reactions
GI-related effects like diarrhoea, constipation, and nausea are very frequent symptoms following the first one or two doses with weight loss products.
You need to see the doctor immediately if you experience severe abdominal pain which can extend to your back as it might indicate you have developed pancreatitis.
If vomiting or diarrhoea happens with the regularity or intensity which leads to your dehydration, kidneys are at risk too. Gastrointestinal side effects and the TGA warning on dehydration caused by semaglutide have led the manufacturers to revise their product information.
Precautions
Tell your doctor before using Livarise if you have:
- A history of pancreatitis
- Severe gastrointestinal problems or delayed stomach emptying
- Kidney problems
- Diabetic retinopathy
- Gallbladder problems or gallstones
- A history of serious allergic reactions to semaglutide
- A personal or family history of medullary thyroid carcinoma or MEN 2
- A planned surgery or procedure requiring general anaesthesia or deep sedation
The use of Semaglutide for weight management during pregnancy is inappropriate. If you plan to become pregnant, consult your doctor about treatment options.
The TGA has issued class-wide warnings with an explanation on the GLP-1 medicines and a serious rare eye condition named non-arteritic anterior ischaemic optic neuropathy (NAION). Any abrupt or aggravating vision changes must be checked quickly.
Livarise and Other Medicines
Tell your doctor about all prescription medicines, diabetes medicines, supplements and other weight-management treatments you use.
Extra care may be needed when semaglutide is used with insulin or sulfonylureas, as the combination can increase the risk of hypoglycaemia.
Because semaglutide slows gastric emptying, it may also affect the absorption of some medicines taken by mouth.
Do not combine Livarise with another semaglutide product or another GLP-1 receptor agonist unless your healthcare professional specifically recommends the combination.
Livarise Storage
Livarise should be stored according to the manufacturer’s instructions.
For semaglutide products of this type, refrigerated storage is generally required. Current product information for Livarise lists:
- Store at 2°C to 8°C
- Do not freeze
- Protect the medicine from inappropriate heat
- Keep out of reach of children
The exact in-use storage period can depend on the particular cartridge and pen system, so follow the instructions supplied with the Livarise package.
Frequently Asked Questions
Can Livarise 15mg/3mL be used simply to lose a few kilograms?
Livarise is a prescription medicine intended for appropriate patients who meet the medical criteria for semaglutide weight-management treatment. It is not intended as a cosmetic weight-loss injection for people who do not have a relevant medical indication.
Why is Livarise increased slowly instead of starting at the full dose?
Gradual dose escalation helps the body adjust to semaglutide and reduces the likelihood or severity of gastrointestinal problems such as nausea, vomiting and diarrhoea.
Can Livarise affect my appetite even if I have not lost much weight yet?
Yes. Semaglutide can affect hunger and feelings of fullness before noticeable changes in body weight occur. Individual responses vary, and weight management should be assessed over time rather than after only a few injections.
Does Livarise work without changing my diet?
Semaglutide is intended to be used alongside a reduced-calorie diet and increased physical activity for weight management. It should not be considered a replacement for healthy eating habits and regular activity.
What should I do if my eyesight suddenly becomes blurred while using Livarise?
Contact a healthcare professional promptly if you experience sudden or significant vision changes. The TGA has recently updated GLP-1 receptor agonist warnings concerning the rare eye disorder NAION, which can cause serious visual impairment.
References
- TGA – Wegovy Australian Product Information
- TGA – Wegovy registration information
- TGA – GLP-1 medicines and anaesthesia safety warning
Medical Disclaimer
Livarise Injection is a prescription medicine and should be used only under the supervision of a qualified healthcare professional. This information is provided for educational purposes and does not replace personalised medical advice, diagnosis or treatment.
