Semasize 1mg Injection contains semaglutide 4mg/3mL (1.34mg/mL) and is administered as a once-weekly subcutaneous injection. The product is manufactured by Alkem Laboratories and is available as a pre-filled pen/cartridge presentation. Alkem launched Semasize, Obesema and Hepaglide as semaglutide brands in India in 2026, with approval for chronic weight management alongside diet and exercise.
For weight management, semaglutide is used alongside a reduced-calorie diet and increased physical activity. Australian TGA information for Wegovy provides detailed information on semaglutide’s weight-management indication, dosing and safety.
What Is Semasize 1mg Used For?
Semasize contains semaglutide, a GLP-1 receptor agonist used as part of a comprehensive weight-management programme. For adults, semaglutide can be prescribed for chronic weight management when:
- BMI is 30 kg/m2 or higher, or
- BMI is 27 kg/m2 to less than 30 kg/m2 with at least one weight-related health condition.
Treatment is intended to be combined with a reduced-energy diet and increased physical activity.
Semasize 1mg is one of the intermediate doses used during semaglutide dose escalation. It is not normally the starting dose for weight management.
How Does Semasize Work?
Semaglutide targets the GLP-1 receptors that play roles in regulating appetite, digestion, and controlling blood sugar.
It is possible that it can assist people in their weight control by:
- Decreasing appetite
- Enhancing the sensation of satisfaction
- Limiting the volume of food consumption
- Slowing gut emptying
- Enabling reduced caloric consumption with passing of time
It should be noted semaglutide is neither a stimulant nor a type of medicinal drug that leads to fat burning directly through the body. Basically, semaglutide’s role in weight management comes down to its appetite-suppressing and food intake-related and also energy balance-related properties.
How To Use Semasize 1mg
Semasize 1mg is administered once weekly as a subcutaneous injection.
It is injected under the skin according to the instructions provided with the pen or cartridge device. Semaglutide is most often prescribed to be taken at the same time every day, whether or not you’ve had any food previously.
The way the injection is given is very important because the wrong injection site such as vein or muscle can lead to very serious consequences. Hence, it is highly recommended that the medical professional should demonstrate proper injection technique.
It is important that you only use the pen and the needles according to the instructions that you will get from the medical provider and you are not to share your injection devices with the other person.
Semasize 1mg Dosage for Weight Management
Semaglutide for weight management is normally increased gradually:
| Treatment period | Weekly dose |
|---|---|
| Weeks 1–4 | 0.25mg |
| Weeks 5–8 | 0.5mg |
| Weeks 9–12 | 1mg |
| Weeks 13–16 | 1.7mg |
| Maintenance | 2.4mg |
Therefore, 1mg once weekly is generally used after the initial 0.25mg and 0.5mg stages. The gradual increase helps the body adjust to treatment and may reduce gastrointestinal side effects.
If a higher dose is not tolerated, your healthcare professional may delay dose escalation or use a lower dose for longer.
Do not increase or decrease Semasize without medical advice.
What Does Semasize 4mg/3mL Mean?
The Semasize 1mg presentation shown contains 4mg of semaglutide in 3mL of solution, equivalent to approximately 1.34mg/mL. The pen/cartridge is designed to provide the prescribed 1mg doses rather than meaning that 4mg should be injected at once.
The exact number of usable doses depends on the specific pen or cartridge presentation and its instructions.
If You Miss a Semasize Dose
If you happen to skip a weekly dose of semaglutide, make sure to check the instructions related to missed doses that your prescriber has given with the package.
A dose that is missed can be generally taken no later than 5 days if you are taking a course of the Australian Wegovy. If it’s been longer than 5 days that you hadn’t taken the dose, you should simply skip that dose and continue with the regular schedule.
You should avoid taking two doses together in close proximity in order to make up for one missed shot.
Possible Side Effects
Common side effects of semaglutide include:
- Nausea
- Vomiting
- Diarrhoea
- Constipation
- Abdominal pain or discomfort
- Headache
- Dizziness
- Tiredness
- Reduced appetite
- Injection-site reactions
During or before any changes in medication or dose, you may frequently experience some digestive side effects. You should contact a doctor immediately if severe and continuous abdominal pain occurs, especially if the pain is moving towards the back.
Very frequent vomiting or diarrhea may lead to dehydration and possibly affect the functioning of your kidneys.
Precautions
Tell your doctor before using Semasize if you have:
- A history of pancreatitis
- Severe gastrointestinal problems or delayed stomach emptying
- Kidney problems
- Gallbladder disease or gallstones
- Diabetic eye disease
- A history of serious allergic reactions to semaglutide
- A personal or family history of medullary thyroid carcinoma or MEN 2
- A planned operation or procedure involving general anaesthesia or deep sedation
It is not recommended to use the drug semaglutide for losing weight during pregnancy. If there is planning of pregnancy, the patient should talk to her/his doctor about this matter.
Some GLP-1 drugs may slow down emptying of the stomach, so it is important to inform your healthcare crew about being on semaglutide if you are going to be in operation or a procedure requiring general anaesthesia or profound sedation.
Semasize and Other Medicines
Inform your doctor about all prescription medicines, medicines for diabetes, dietary supplements, and other treatments for managing weight you are currently taking.
Especially, close attention has to be paid in cases when semaglutide is being given together with insulin or sulfonylureas as this can lead to hypoglycaemic effects.
Semaglutide may, as it slows gastric emptying, also influence the absorption of some orally taken medicines.
You shouldn’t give Semasize together with another semaglutide product or another GLP-1 receptor agonist unless your doctor specifically recommends it.
Storage
Semasize should be stored according to the manufacturer’s instructions.
Current product information for Semasize states:
- Store refrigerated at 2°C to 8°C
- Do not freeze
- Protect the medicine from inappropriate heat
- Keep it out of reach of children
Frequently Asked Questions
Can Semasize 1mg be used as the first semaglutide injection?
Usually, no. The standard weight-management schedule begins at 0.25mg and increases gradually through 0.5mg before reaching 1mg. Starting directly at 1mg may increase the risk of gastrointestinal side effects and should only be done if specifically directed by a healthcare professional.
Why might weight loss slow down after several months of treatment?
Weight loss does not always occur at the same rate throughout treatment. Changes in calorie intake, physical activity, treatment duration, individual response and other health factors can all affect progress. A period of slower weight loss does not necessarily mean that semaglutide has stopped working.
Can Semasize 1mg cause burping or indigestion?
Yes. Indigestion, abdominal discomfort and other gastrointestinal symptoms can occur with semaglutide because it affects digestion and gastric emptying. Persistent or severe symptoms should be discussed with a healthcare professional.
How should the Semasize pen be checked before an injection?
The solution should be checked according to the manufacturer’s instructions before use. It should generally appear clear and colourless and free from visible particles. Do not use an injection if the solution looks abnormal or the device appears damaged.
When should my response to Semasize treatment be reviewed?
Your doctor should review your progress periodically, including changes in body weight, side effects, other medical conditions and how well you are following the overall weight-management plan. The decision to continue or adjust treatment should be based on your individual response rather than weight change from a single week.
References
Medical Disclaimer
Semasize 1mg is a prescription medicine and should be used only under the supervision of a qualified healthcare professional. This information is provided for educational purposes and does not replace personalised medical advice, diagnosis or treatment.
